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The game is set in a world managed by the balance of Nexus, unseen bonds woven between paired concepts such as love and hate. When these bonds are severed, they scatter their power in the form of creatures named Anima. Players control a traveler embarking on an adventure to forge bonds with Anima.

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Arknights: Endfield takes place on a moon called "Talos-II", and the player takes upon the role of the "Endministrator" of the titular "Endfield Industries" corporation.

The moon Talos-II was colonized 152 years prior to the beginning of the game's story by pioneers from Terra, the planet that serves as the setting of the previous game, accessing it through a dimensional portal known as an "Cosmic Gate" This portal was destroyed approximately a century before the events of the game, leaving the Terran pioneers stranded on Talos-II. Several concepts, factions and characters from Arknights appear, such as Originium, an energy-rich mineral enabling the use of special pseudo-magical abilities called "Arts", and "Rhodes Island", the pharmaceutical corporation which the player character belonged to in Arknights.

Similarly to Terra, Talos-II is a world of natural disasters known as "Catastrophes", most notably a dangerous supernatural disaster called "Corruption", which causes distorted environments and abnormal physical phenomena in the affected areas. Much of Talos-II is wilderness and no-man's land. An endemic species of creatures called "Aggeloi" act as the primary threat to civilization; while armed raiders known as "Landbreakers" live in the fringes of society making a living off scavenging and crime. The pioneers belong to different nations and organizations, cooperating and competing with each other on a regular basis.

With the resumption of the exploration of the ruins by the major powers of Talos-II, the Protocol Recycling Department was rebuilt under the leadership of Endfield Industries' Superintendent Perlica. The Endfield Engineering Center has integrated a large number of prototype equipment from the Protocol Recycling Department and successfully developed the "Automated Industry Complex". In order to prove the reliability of the system's transmission technology, the Protocol Recycling Department chose "Valley No. 4", the most barren area of Talos-II, as its target, attempting to use it as the basis for its gradual exploration outwards.

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According to Bloomberg’s sources, studio design director Josh Sawyer will reportedly be leading the team on a new Fallout game. Bloomberg‘s sources say the strategy is “in flux” and could change. Prior to this, Sawyer was reportedly directing an RPG that was “similar structurally and thematically” to Fallout, but wasn’t actually part of the Bethesda-owned universe.

A WARN Act notice confirms that 52 people have been laid off from the Irvine-based studio’s California office, roughly a quarter of Obsidian’s overall headcount. The now-canceled Avowed sequel was apparently on track to be revealed within the next year, but “did not fit into” new Xbox CEO Asha Sharma’s strategy, presumably because Avowed/Pillars of Eternity is not considered a pillar franchise for the brand, and the original game apparently failed to meet sales expectations.

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