Corey Hawkins as Eric Carter, an ex–Army Ranger who has returned to America and is determined to stop the terrorist attacks that may follow.
Miranda Otto as Rebecca Ingram, the former head of CTU, and the wife of Senator John Donovan, who is running for President of the United States.
Jimmy Smits as John Donovan, a Senator who is running for President, and Rebecca Ingram's husband.
Teddy Sears as Keith Mullins, the ambitious and driven head of CTU, who previously worked under Rebecca.
Dan Bucatinsky as Andy Shalowitz, a communication analyst at CTU who is trusted by Rebecca and is unhappily paired with computer analyst Mariana.
Anna Diop as Nicole Carter, a nurse and Eric's wife.
Ashley Thomas as Isaac Carter, older brother of Eric who is angry at him for their bitter past involving Eric's wife, Nicole.
Charlie Hofheimer as Ben Grimes, Eric's former comrade in the Army Ranger unit who is now suffering from PTSD.
Coral Peña as Mariana Stiles, a bright, young, self-taught computer analyst and cousin of former CTU agent Edgar Stiles, who is paired with Andy.
Sheila Vand as Nilaa Mizrani, the campaign director of Senator John Donovan.
Veronica Cartwright as Margaret Donovan, Senator John Donovan’s mother.
Raphael Acloque as Jadalla bin-Khalid, a university student who has embraced his father's jihadist campaign since his death.