The year is 2020, and Phil Miller (Will Forte) is seemingly the only human left on Earth after a deadly virus swept the planet one year earlier. An average man "who likes Star Wars, Twinkies, and sex", Phil searches North America in his RV for other survivors. After a long journey and returning to his hometown of Tucson, Arizona, Phil believes he is Earth's last surviving human. Just before he commits suicide out of loneliness and a desire for a female companion, his wish comes true, and he meets Carol Pilbasian (Kristen Schaal), a shrill, nagging, and eccentric woman.