I think what worried me most about that quote was the satirical part, and I didn't really get that vibe from what was put out. It may have been an intent at first, but editing and all that probably trimmed some potential over-the-top stuff. In the end, I think it was spoken somewhat to be a counter-point to the Twilight culture of the time where people were more about romanticizing vampires than accepting they were monsters.
Approaching the plot pragmatically, what we've seen isn't really "new" in the grand scheme of things. SotN treated us to a flashback to Alucard's mother's death via the dream with the succubus. This just added some more context to it by outlining how she met Dracula. Overall, I'm glad they portrayed the church as the assholes they were, since it succeeded in part to making Drac a sympathetic villain by having him go John Wick on Christianity. Come the start, it seemed like he was intent with just keeping to himself as let on by the line about giving up on impaling people. When it came to the Belmonts, we obviously knew they were a thing, with the church's dickishness and their exile just being a natural progression even if something I never specifically recall of game lore. Stuff with Sypha's clan is new, but at the same time, it's not like she really got a lot of storytelling in III. Conspicuously absent in this was Grant, if III was the primary source material. Of course, there's still room to write him in with future stuff.
One of the more interesting aspects, I felt, was Dracula seemingly took advantage of his immortality for the pursuit of knowledge. I think there was a line about his castle literally being mobile, but in general, he also seemed to have an understanding of technology way beyond the rest of the world. Stuff like the clock tower or lab stages always seemed a bit out of place in the games depending on how far back in time you went, but this seemed to be a quiet nod in acknowledging their presence. I'm kinda hoping we get some backstory on how he turned, be it some kind of Faustian deal or even by accident. Though I can understand not everyone might get behind that since the games have attempted it in their own ways in the past.
Either way, even when this leg of the plot finishes, we could get even more seasons with future Belmont generations, or even dabbling into stuff with Soma or Shanoa.