it's been a while since i took biochemistry but
it would be unprecedented to observe biological life devoid of oxygen and hydrogenhydrogenoxygen, but there have been a few academic papers positing methane as a viable alternative, particularly in the too-cold-for-liquid-water conditions found on Titan. methane has a much lower freezing point than water allowing it retain a liquid state under the moon's conditions, Titan appears to have a plethora of the all-purpose-lego four valence electron wonder element carbon with which it can bind (it's ironic most people consider water the indispensable precursor to biological life when carbon is likely more vital), and methane-family compounds can form both stable membrane structures and porous lipid bylayers, ensuring both the rigidity needed for connected cell structures and the permeability needed for cells to transport organic matter both into and out of the cell.
improbable? sure, all biological life is an extraordinarily improbable event, but methane is a more promising water replacement chemical compound than most. but as the article points out our understanding of the conditions on Titan is very limited and we may be theorizing around faulty parameters.