Granted it's sitting about a year away, I saw this teaser put up on the official site. (Spoiler in the video if you want to be surprised.)
Needless to say, I shat bricks. From the story perspective I'm anticipating this like Mass Effect 2. I fucking love the Tiberium storyline and C&C3 just turned me into a complete and utter fanboy. So even with the extreme changes they're making for the game, I'm still looking forward to it. They've already said that the ascension Kane's been referring to all these years will be properly revealed.
Trying to put fanboyism aside, the changes are extreme, but they seem to be ones to rejuvenate the RTS series in general. I'm scared on one hand after seeing how RA3 was done. Unless the later patches changed the game drastically, RA3 was utter shit. The blog entries I've read said that they're proud to present C&C4 to fans of C&C3, not C&C fans in general, which is an important distinction. (And leads me to believe they aren't happy with RA3? idk.) Either way, given how high quality C&C3 is/was, I'm daring to stay hopeful for a fun game as well. C&C3+Kane's wrath was fun as hell, both story and gameplay wise.
Jesus fuck 2010 can't come fast enough for all the games I want. D:
Edit: Joseph D. Kucan is such a badass too. Anything with more of him in it is win; I'm sorry.