Marijuana: Chester the Brain Molester

[Pikarya]

A lot of sweet baby greens. Midnight snack.

[Hatedregret]

Very jealous.

[Pikarya]

http://anony.ws/i/2013/03/23/1qbrH.jpg

[Aurara]

Do want

[Pikarya]

http://medicalmarijuana411.com/mmj411_v3/?p=14219

This study examines the concept of clinical endocannabinoid deficiency (CECD), and the prospect that it could underlie the pathophysiology of migraine, fibromyalgia, irritable bowel syndrome, and other functional conditions alleviated by clinical cannabis.

METHODS: Available literature was reviewed, and literature searches pursued via the National Library of Medicine database and other resources.

RESULTS: Migraine has numerous relationships to endocannabinoid function. Anandamide (AEA) potentiates 5-HT1A and inhibits 5-HT2A receptors supporting therapeutic efficacy in acute and preventive migraine treatment. Cannabinoids also demonstrate dopamine-blocking and anti-inflammatory effects. AEA is tonically active in the periaqueductal gray matter, a migraine generator. THC modulates glutamatergic neurotransmission via NMDA receptors. Fibromyalgia is now conceived as a central sensitization state with secondary hyperalgesia. Cannabinoids have similarly demonstrated the ability to block spinal, peripheral and gastrointestinal mechanisms that promote pain in headache, fibromyalgia, IBS and related disorders. The past and potential clinical utility of cannabis-based medicines in their treatment is discussed, as are further suggestions for experimental investigation of CECD via CSF examination and neuro-imaging.

CONCLUSION: Migraine, fibromyalgia, IBS and related conditions display common clinical, biochemical and pathophysiological patterns that suggest an underlying clinical endocannabinoid deficiency that may be suitably treated with cannabinoid medicines.

Republished from:
http://www.ncbi.nlm.nih.gov/m/pubmed/15159679/

[Pikarya]

[Salodin]

Amazing that it happens this saturday. So excite.

[Pikarya]

seen this on reddit lol

[djzombie]

so jelly

[Gokku]

I've got 2 grams of sour d I am going to smoke and drink till I pass out Saturday, I'm a lightweight.

[Aurara]

I'm fucking pissed I can't smoke on 4/20 this year, so jealous of you guys....2 more weeks before I can smoke again...

[Pikarya]

I heard people at Western Kentucky University currently are smoking out on the courtyard with cops lol.

[Draygon]

Hrm, just a gram of what I have for this Saturday... verdict?

Spoiler: show

http://imageshack.us/a/img11/7014/imag0095tx.jpg

[Salodin]

Get more? Only day of the year where we pretend to have a legitimate excuse to get shit faced. Plus, your dealer probably has fresher then normal product since he's selling it faster this time of year.

[Pikarya]

My guy had some of the most insane strains. I wasted all my funds like it was a Steam sale.

[Boyiee]

I wish some of you lived nearby.

[Salodin]

Any one in the soflo area? Specifically coral springs/parkland area?

[Aurara]

Anyone in northern cali, specifically Sonoma County(Rohnert Park, Petaluma, Windsor, Cotati)? I might end my T-break early

[Kohan]

seen this on reddit lol

This is what that's related to: http://usatoday30.usatoday.com/news/...ply/50581346/1

[Hitoshura]

Happy 4/20 guys, just another day for me. Well not really, copped some blue dream, and some decent bubble hash to sprinkle on it. Going to be a great day, got a UFC fight card to watch, BBQ feast to cook, beers to drink, and even a boxing match later to watch. Smoking all day.

What are you all doing? Anyone heading to Hippy Hill?