Try making this into a .reg file and merging it
Code:
[-HKEY_CURRENT_USER\Software\Classes\.exe\shell\open\command]
[-HKEY_CURRENT_USER\Software\Classes\secfile\shell\open\command]
[-HKEY_CLASSES_ROOT\.exe\shell\open\command]
[HKEY_CLASSES_ROOT\.exe]
@="exefile"
"Content Type"="application/x-msdownload"
[-HKEY_CLASSES_ROOT\secfile]
It just resets the .exe file settings. It is a fairly common thing with new spyware to messup. Thou it normally changes it so no matter which program you try to run it opens a fake AV / error message. This type of malware normally only effects one user account so logging into another is the easiest way to remove it. MSE is shockingly good at removing this when Malwarebytes fails. Combofix should be a last resort, it will get rid of it but might make windows unbootable in the process.