Grahdens 7* has 50% all stats with -15% light/dark damage, ES with 8bc/turn for party, status negate on BB, shield and OD boost on SBB.
The only time you NEED status, stage 2 turn 2/3 you can UBB your isterio sub on turn 1. I just relied on Reeze. But if you take Grah friend can use Klaus if you have and ride an 85% sicknes infliction + ATK>DEF buff on BB/SBB.
Up to you but the only thing isterio lead offers imo is +100% ATK against status afflicted enemies but that shit is negligible compared to survivability and gauge management.
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