One of the scariest duos right now is Loki w/ Cloak & Dagger. Being able to cycle that ult in every teamfight is absurdly strong, and the duo are excellent at disengaging from dive pressure and covering one another's big buttons. Green runes + light bubble = near-impossible to kill and Loki is exceptional at holding the frontline healing line while C&D aim up and top off the flying DPS.
Another disgusting combo is Loki w/ Luna. Same deal regarding the ult cycling, and the duo deals disgusting damage and spike healing when needed. With Luna's CC, the duo slaughter solo divers and Luna's strong ult also allows for Loki to instead ult offensively without worrying about leaving the team unsupported, allowing for hilarious bunker-bustering combos like double iron man (Rip enemy healer ults), double Hela (the ultimate point defense), double Star Lord (hope you have a healing ult) or staggered Moon Knight (a busted ult that needs nerrrrrrfs.)
I'm currently in plat running a C&D/Loki duo and its a ton of fun.
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