40k IS is 13 1/3 runs, less if no captain, khroma is 25% droprate (there's 4 items for that slot, assuming equal distribution isn't very far-fetched). It's a guaranteed 12k per run, plus NPCables; say 20k per run on average (reality it might be a bit more) plus khroma odds.
Khroma: 1.33M for 400k khroma
Rest: 266,67k
Opportunity cost of perdu wand: 1.6M
Unless you are completely unable to ever do ISNM due to time constraints or only having like, PUP75 or SMN75. Time constraint eh, not likely.
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