Yea I could kill Baal with 2-3 poison dagger strikes with the right setup and Lower Resist. Anything with +poison damage stacks but the DPF and duration is averaged. It takes a long ass time to get the right facets and charms needed since you have to grind Mephisto, but it is doable. The trick is to have a high enough averaged poison with the highest amount of duration mixed with anything that pure increases damage% and reduces resistance% to compensate for the reduced DPF. Eventually you can get ~900K poison damage that might last around 3~4 minutes. Open wounds stacks with this too, but I never found anything worth wile to replace my Black Bog's dagger.
What really helped (and ruined my first account) was a glitched charm that had 900k damage over 12 seconds. It was glitched because the damage kept changing every time I logged in and I think the highest damage was over 3 million/12 seconds. That was the only way I could one shot his ass instead of the usual 2-3 stabs.
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