I find it hard to. If they're moving the arrow rarely hits, and when they're still, it's always to the point where I have to shoot 3-4 arrows to get the right angle to hit them at their distance, at which point I end up having to dodge their attack screwing that all over, and then I get to sit on my ass again waiting for them to stop.
Btw, in 4-2 after the second grim reaper you kill...
Spoiler: show
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