These are all just my personal opinions. I'm not a typical crafter.
Leather (my main on Thistle) -- 2/10. I never ever ever use it for personal synths, only synths for others. I leveled it to 80-something while my highest job was WHM 30-something, so it was a bitch to level. Only reason it doesn't get a 1/10 is because of the tips it brings in by synthing for others. I'd never level leather again.
Cloth -- 3/10. He's still in progress, so I might not be a fair judge of the craft. I have no idea why I decided to make a cloth mule, other than it's one of the only crafts I didn't have a mule yet for. I doubt he'll be much use, plus I'm really not having fun skilling him.
Gold -- 4/10. I enjoy being able to HQ stuff for my LS, and sometimes I actually synth things to sell. Having high gold is also useful when leveling various crafts on other mules.
Bone -- 6/10. My lowest level mule (80-something), but she's stopped there on purpose. Her only purpose in life is making RR objects for myself and my LS. Good support for leveling other crafting mules though.
Wood -- 8/10. My second most moneymaking mule. Cheap and fast to level, lots of area for profit if you know where to look.
Alchemy -- 9/10. Like wood, only better. My most moneymaking mule. Cheap and fast to level, tons of profit to make if you know where and when to synth.
Hm, hope I'm not forgetting one... I tend to lose track of my mules nowadays.
Edit: Can I rate my stable of mules as a whole? I love the synergy of having so many crafting mules, I enjoy being able to take a raw material and send it to a mule for a synth, to the next mule to make it worth more, to the next mule to make it worth even more, etc. I feel like I have my own mini-industrial nation going on here. 10/10 for overall satisfaction, helpfulness to LS, and ability to do the majority of snyths that exist.
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