House: We found a tumor.
Dad: She has cancer.
House: Technically, no.
Dad: So its not cancer?
House: No, it’s cancer. But, he has cancer, on his left testicle.
Alex: I don’t have testicles.
Dad: She’s not a guy.
House: His DNA says you’re wrong. Frogs and snails and puppy dog tails. You’ve got male pseudohermaphroditism. See we all start out as girls and then we’re differentiated based on our genes. The ovaries develop into testes and drop. But in about 1 in 150,000 pregnancies a fetus with an XY chromosome, a boy, develops into something else. Like you. Your testes never descended because you’re immune to testosterone. You’re pure estrogen, which is why you get heightened female characteristics; clear skin, great breasts. The ultimate woman is a man. Nature’s cruel, huh?
Dad: This is obviously a joke, this is impossible.
House: No, a joke would be me calling you a homo. See the difference? I’ll schedule him for surgery.
Alex: (She gets out of bed.) No, you’re wrong. I’m a girl. (She pulls off her gown.) Look at me! How could you say I’m not a girl? See! They’re all looking at me. I’m beautiful!
House: Anger, it’s just the cancer talking. Put your clothes back on. I’m going to cut your balls off. Then you’ll be fine. (She covers up, crying and looks at her dad who turns to look out the window.)