Initially only available in the US, YouTube Red will cost $9.99 (£6.50) a month and have no adverts.
PewDiePie, Rooster Teeth and Lilly Singh are among the well-known names involved.
Analysts suggested it could be difficult to turn millions of fans who expect free access to pay up.
YouTube will offer US-based users a month's free trial of Red from 28 October. International pricing and launches will be announced soon.
"For years, YouTube's fans have been telling us they want more," the company wrote in a blog post.
"More choice when watching their favourite content, more ways to support their favourite creators and, above all, the option to watch their favourite videos uninterrupted."
YouTube Red original shows will include:
- Scare PewDiePie - a reality adventure series as Felix reacts to situations inspired by his favourite games.
- Sing it! - A comedy that satirises talent competitions
- Lazer Team - A movie featuring four losers who find an alien ship carrying an strange cargo
- A Trip to Unicorn Island - An in-depth look at the life of Lilly Singh as she embarks on a 26 city tour.
- Single by 30 - a romantic drama about two high school friends who pledge to marry each other if they are still unwed at 30
- Fight of the Living Dead - a reality show that puts popular YouTubers in a frightening zombie apocalypse to see how they cope
- I Am Tobuscus - a comedy about a self-involved YouTube creator trying to be a big star
The roster also includes some as yet untitled items such as a show based around the science of video games that will be filmed for VR headsets, a reality series that puts YouTube stars into a murder mystery setting and an anthology looking at the absurdity of internet culture.
YouTube content will be able to be downloaded and watched offline, a contrasting approach to Netflix - its chief product officer last month said offline viewing wasn't something users wanted.
The subscription will include access to YouTube Gaming and a new YouTube Music app, also announced on Wednesday. Google's streaming music service, Google Play Music, will also be included.