You would need to set specific spells and get specific merits to get any decent numbers on any nuke, really. In my oppinion, you might as well go for a Cannonball setup instead, since meriting for physical spells is going to be more beneficial overall (elsewhere). And you'll get higher numbers out of Cannonball anyway. :/
Only problem is that most of Cannonball's gear comes from the AH, and have big price tags. Most of the gear needed for mind blast/eyes on me comes/regurgitation is r/ex. Though... If you want to nuke, you should probably just level BLM. It's a shame SE didn't make our nukes more worthwhile when they did SMN merit BPs.
EDIT: More power to you if you're asking about physically resistant mobs though. >.>