Elemental Seal bypasses target's m.eva check but doesn't ignore elemental resistances and status immunities, which is why you may get a random resisted ES nuke on high level NMs, and something like ES Thunder4 or ES Stun will never fully land on a Thunder Elemental (or land at all, in Stun's case).
Fully merited Focalization is useful if you can take advantage of it during Tabula Rasa with proper macro sets, it's not worth using outside of it.
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