If you're facing ground unit, block both entrance to your base with 4-5 bunkers and a ton of tank behind (hero tank, normal tank), and constantly have 2-3 scv repair them. You can ignore the entrance to the relic since the zerg will go for your bunkers. Make banshee to snipe the nydus
If you're facing air unit, make as many viking as you can (2 starport with reactor work well usually), and a few bunkers/tank to defend against ground. (might want to put 1 firebats in each since you will see lot of zergling). Kill the big guy when it show up.
If you have psi disruptor, use it against ground unit. If you have the mind control tower, use it as often as you can on ultralisk/broodlord.
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