I used to camp Mee Deggi the Punisher when it was camped by gilsellers. I managed to get it about half the time. I am quite familiar with it's pop conditions when it used to only pop in the center island, and then when it would pop anywhere in the courtyard. Then when they made it's drop items rare/ex they divorced Mee/Quu from their placeholder.
I kept track of the 8 yagudo's in the perimeter, the two yagudo's in the center, and the one yagudo that can move between the perimeter and the center. I found that when Mee/Quu, the pop does not replace the pop of any other yagudo in the area. The rest of the yagudo's will pop as if Mee/Quu never existed. Before, Mee/Quu shared a spawn with the yagudo that is able to move between the perimeter and the center.
When I discovered this I did exactly as you suggested with Mee Deggi the Punisher. I cleared all the yagudo's and waited for Mee Deggi to pop. Incidentally 8 yagudo's were in the perimeter, 2 in the center, 1 that could move between center and perimeter, and Mee Deggi the Punisher were up as I entered. After the room filled again with all 11 yagudo's, they were not touched until Mee Deggi once again appeared. 1 hour after ToD, Mee Deggi the Punisher popped. 12 Yagudo's were once again in the room.
It wasn't unusual to wait 4 hours for Mee/Quu to pop when it had a placeholder. It isn't unusual to wait that long now. Don't bother counting the minutes between the yagudo pops for Mee/Quu because it won't help you. All you can do is wait for 1 hour after ToD and then wait some more.
TL;DR:
Mee Deggi the Punisher and Quu Domi the Gallant no longer have placeholders
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