Imo, Health quints/movement, Magic pen red, Armor yellow/Health per lvl, magic resist per lvl blue.
Singed is a tank, 0/21/9 is great for him. The argument for dodge runes is that, sure the extra 10% movement is nice for chasing, but keep in mind, if you are running ghost + your ult + your W, i'm sure you will be able to catch that person and fling them.
As for items, I tend to rush rod of ages, just because it gives me a little bit of everything for surviving early game. If not, depending on the team, go for whatever defensive item you can after building catalyst.
I do not think you can go wrong with Catalyst first on singed, especially if you aren't running mp5 runes on him.
Right now I run for tanks Health quints/Red magic pen/Yellow health per lvl/ and Magic resist per lvl.
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