Orphan's Cradle is a festival of "how can we make this place look cool while we extend the game for another 2+ hours". I love the game and I actually love this area because it is a huge challenge after challenge.
That being said, the key here for me was to debuff mobs quite a bit. I ended up using a default Sab/Med/Syn set up to start most fights and just spammed Fog and Pain on everything in the field while I was healed and buffed. Sanctum Templars SUCK as do those lame ass motorcycles. But all are susceptible to Pain and Fog which just makes them wander around aimlessly doing you no harm. The Sacrifices that spam death on you are also susceptible to Fog which pretty much negates most of their damage output so you can concentrate fire on whatever major monster is combined with them.
Another tip for some of the final gold sister area is that since each is on a jumpable platform, aggro and run off, when they turn their back you can get an easy preemptive, ruinga the lowhp stuff and go to town.
The Gold sister area with the "trash pull from hell" that you speak of is insane. I didnt grind but still had fang with 9k+ hp and still this would own me quick. However, you can skip it if you are fast, which is what I did. You can skip all but the gold sister's final pull before he fight.
Oh and props to SE for giving us a Magus Sisters reference. Gotta love it.