oes your existing Dell chassis have a removable I/O shield or is it part of the chassis? Is the front panel header a 2x5standard 10 pin header with pin #10 missing or is it a 2x8 or 2x10 header?
On some Dell's the I/O shield was removable and if yours is removable it can be installed in another chassis? If the front panel motherboard header is a standard 2x5 header with pin #10 missing you shouldn't have to do much on the front panel re-wiring.
You may have a problem with motherboard stand-offs (risers) and alignment of the I/O ports and I/O shield since on many machine Dell doesn't use stand-offs they use raised areas as standoffs on the bottom of the chassis.
In most cases transferring a proprietary motherboard to another chassis will present some problems. Some are easy to correct and some are not so easy to correct. Whether you should attempt the change or not is dependent on your skills and the tools you have available for use.